Drug points: Transient hemiparesis with topiramate

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Probable topiramate-induced hemiparesis.

Topiramate is a broad-spectrum antiepileptic medication that is used as monotherapy or in combination with other medications to treat epilepsy in both adults and children. It is also indicated for migraine prophylaxis in adults. An off-label use of topiramate is as a mood stabilizer (with no associated weight gain) in rapid-cycling and mixed bipolar episodes. The mechanisms of action of topiram...

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Reversible hemiparesis associated with the use of topiramate

We report a case of a 5-year-old boy with intractable partial seizures who developed a transient hemiparesis, worsening of the electroencephalogram (EEG) and a change in his seizure pattern with increased seizure frequency after receiving topiramate (TPM). Symptoms resolved within a month after TPM was discontinued. Clinicians need to be aware that TPM use may occasionally be associated with fo...

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Topiramate induced acute transient myopia: a case report

INTRODUCTION Topiramate is a sulfamate-substituted monosaccharide mainly used to treat epilepsy in children and adults and for prophylaxis of migraine. This article describes a case of topiramate induced acute transient myopia. The underlying mechanism and management is discussed. CASE PRESENTATION A 34-year-old female complained of sudden onset of blurred vision, 9 days prior to this she had...

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Reversible injury of internal capsule and splenium in a patient with transient hypoglycemic hemiparesis.

Case Report A 78-year-old woman with no history of stroke was taken to the Guro Hospital emergency department after being found dysarthric and less responsive at home. Her husband noted that on the day of admission she developed diaphoresis and tremulousness after not having two consecutive meals, followed by dysarthria, right-sided weakness, and somnolence. She was diagnosed as having type 2 d...

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Urolithiasis associated with topiramate.

OBJECTIVE Topiramate is a sulfamate-substituted monosaccharide anticonvulsant used as adjunctive therapy for intractable refractory seizures. It is report a case of topiramate-induced urolithiasis. CASE REPORT A 35-year-old man presented with acute, right-sided, colicky flank pain. He denied hematuria or dysuria. He was in use of phenytoin, risperidone, phenobarbital, and topiramate. The tota...

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ژورنال

عنوان ژورنال: BMJ

سال: 1999

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.318.7187.845